FIG 2.

In vivo efficacy of MB-1, either alone or in combination, against wild-type (WT) P. aeruginosa strain JJ4-36 and its isogenic pyoverdine biosynthesis (pvdA) or secretion (RTQ) mutant in a neutropenic mouse model of thigh infection. Numbers above each data point represent the mean change in numbers of CFU after 24-h relative to 0-h control animals. Efficacy was determined using, where appropriate, Student's t test or analysis of variance followed by a Tukey test for multiple comparisons. Each treatment was statistically different than the control (P < 0.001); for wild-type strain JJ4-36, combined treatment with MB-1 and reserpine was also statistically better (P > 0.001) than reserpine or MB-1 monotherapy, which were not statistically different from one another (P = 0.06).