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. 2015 Mar 11;59(4):2179–2188. doi: 10.1128/AAC.04618-14

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FIG 1 — Composite model describing the plasma PK of ribavirin as well as its intracellular kinetics in both RBCs and PBMCs. CL_t: total clearance. V_c: central compartment volume of distribution. CL_d: distributional clearance. V_p: peripheral compartment volume of distribution. k_a: absorption rate constant. k_mp: transport/formation rate constant for ribavirin monophosphate (RMP). k_mpout: rate constant for the disappearance of phosphorylated ribavirin. R_dpmp: rapid equilibrium partition coefficient between ribavirin diphosphate (RDP) and RMP. R_tpdp: rapid equilibrium partition coefficient between ribavirin triphosphate (RTP) and RDP.