TABLE 2.
Population estimates for the parameters of the plasma ribavirin PK model without and with covariatesa
| Parameter (unit) | Estimate (relative SE) |
|
|---|---|---|
| Without covariates | With covariates | |
| AIC | 40.9969 | −20.5383 |
| CLt (liters/h) | 14.7 (7.98) | 17.0 (13.1) |
| Vc (liters) | 769 (15.7) | 756 (18.3) |
| ka (h−1) | 2.91 (32.4) | 2.58 (48.9) |
| CLd (liters/h) | 104 (11.4) | 103 (16.1) |
| Vp (liters) | 3,570 (11.1) | 3,460 (13.5) |
| Proportional error | 0.162 (2.16) | 0.162 (2.70) |
| IIV CLt | 33.2 (26.4) | 22.9 (23.1) |
| IIV Vc | 46.4 (30.8) | 41.7 (58.2) |
| IIV ka | 114 (58.7) | 95.7 (89.8) |
| IIV CLd | 42.0 (32.4) | 43.1 (43.5) |
| IIV Vp | 41.0 (33.3) | 17.8 (97.8) |
| Value representing effect of: | ||
| WT on Vc | 1.29 (50.6) | |
| WT on Vp | 0.725 (79.7) | |
| CrCL on CLt | 0.885 (30.4) | |
| Telaprevir on CLt | 0.853 (16.8) | |
| Sex on Vp | 0.732 (19.9) | |
| ITPA on CLt | 0.779 (16.9) | |
| ITPA on Vp | 1.52 (24.5) | |
a
IIV, interindividual.