TABLE 3.
Population estimates for the parameters of the intracellular kinetic RBC and PMBC models without and with covariatesa
| Parameter (unit) | Estimate (relative SE) |
|||
|---|---|---|---|---|
| PBMC | PBMC with covariate | RBC | RBC with covariate | |
| AIC | 3,275.09 | 3,256.32 | 4,523.26 | 4,503.86 |
| kmp (pmol/106 cells)/(μg/mlh) | 1.11 (14.8) | 1.10 (16.2) | 0.0231 (36.6) | 0.0238 (39.3) |
| kmpout (h−1) | 0.617 (14.7) | 0.755 (18.6) | 0.0184 (28.7) | 0.0188 (29.1) |
| Rdpmp | 0.483 (14.9) | 0.379 (14.7) | 4.26 (26.8) | 3.59 (25.7) |
| Rtpdp | 6.85 (12.7) | 7.94 (20.2) | 8.18 (8.78) | 8.23 (9.08) |
| IIV kmp | 49.4 (43.9) | 49.5 (55.3) | 85.8 (39.9) | 85.1 (46.8) |
| IIV kmpout | 55.7 (27.8) | 49.4 (54.1) | 69.9 (39.7) | 70.1 (40.7) |
| IIV Rdpmp | 35.8 (40.5) | 27.6 (58.4) | 46.2 (46.0) | 37.3 (49.1) |
| IIV Rtpdp | 30.8 (34.9) | 22.2 (77.6) | 27.0 (25.7) | 27.3 (47.2) |
| Res RMP | 0.382 (9.00) | 0.390 (11.7) | 0.506 (14.6) | 0.503 (14.6) |
| Res RDP | 0.471 (9.46) | 0.465 (10.7) | 0.395 (10.2) | 0.395 (11.3) |
| Res RTP | 0.389 (5.71) | 0.395 (6.66) | 0.313 (7.23) | 0.315 (6.99) |
| Value representing effect of: | ||||
| Telaprevir on Rdpmp | 1.51 (20.2) | |||
| Telaprevir on Rtpdp | 0.669 (17.3) | |||
| ITPA on kmpout | 0.697 (31.7) | |||
| ITPA on Rdpmp | 1.28 (29.6) | 1.55 (15.7) | ||
a
Res, residual.