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Effects of SQ109 on amastigotes, and synergy with posaconazole. (A) Effect of SQ109 on intracellular amastigotes. (B) Isobologram for posaconazole and SQ109 against intracellular amastigotes; the IC50s are plotted for the drugs acting alone or in combination. The FICI is 0.48 and indicates synergy. (C) Effects of SQ109 on LLC-MK2 cells. The bars represents the means ± standard deviations (n = 3).
