FIG 7.

Efficacy of DNAC-1 in a murine subcutaneous infection model. Each group of mice (6 each) was injected with 10⁸ CFU of USA300, along with DMSO (control), DNAC-1 alone, or DNAC-1 plus oxacillin (oxa). (A) Animals were examined for bacterial abscess for 8 days postinfection and then sacrificed. The lesions were biopsied and CFU recovered from the zone of infection. The asterisks denote P values of <0.05, as determined by a Kruskal-Wallis one-way ANOVA between DNAC-1 and the control and between DNAC-1 with oxacillin versus the control. (B) Histological changes in the punch biopsy sample. Note the presence of bacteria and loss of subcellular architecture in the control sample infected with bacteria alone. The original magnifications for the images are 40× (left and center) and 10× (right).