TABLE 1.
Cumulative MIC distribution for RX-P873 when tested against 657 Enterobacteriaceae and 402 nonfermentative Gram-negative bacilli
| Organism group (no. of strains tested) | No. of strains (cumulative %) at an MIC (μg/ml) of: |
MIC (μg/ml) |
||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ≤0.015 | 0.03 | 0.06 | 0.12 | 0.25 | 0.5 | 1 | 2 | 4 | 8 | 16 | ≥32 | MIC50 | MIC90 | |
| Enterobacteriaceae (657) | 0 (0.0) | 0 (0.0) | 2 (0.3) | 188 (28.9) | 287 (72.6) | 122 (91.2) | 39 (97.1) | 15 (99.4) | 1 (99.5) | 1 (99.7) | 1 (99.8) | 1 (100.0) | 0.25 | 0.5 |
| E. coli (202) | 0 (0.0) | 0 (0.0) | 2 (1.0) | 111 (55.9) | 78 (94.6) | 8 (98.5) | 2 (99.5) | 1 (100.0) | 0.12 | 0.25 | ||||
| K. pneumoniae (202) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 52 (25.7) | 117 (83.7) | 28 (97.5) | 2 (98.5) | 3 (100.0) | 0.25 | 0.5 | ||||
| E. cloacae (50) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 3 (6.0) | 21 (48.0) | 23 (94.0) | 3 (100.0) | 0.5 | 0.5 | |||||
| E. aerogenes (50) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 14 (28.0) | 30 (88.0) | 5 (98.0) | 1 (100.0) | 0.25 | 0.5 | |||||
| C. freundii (51) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 5 (9.8) | 22 (52.9) | 19 (90.2) | 4 (98.0) | 1 (100.0) | 0.25 | 0.5 | ||||
| Proteus spp. (51)a | 0 (0.0) | 0 (0.0) | 0 (0.0) | 1 (2.0) | 4 (9.8) | 9 (27.5) | 24 (74.5) | 9 (92.2) | 1 (94.1) | 1 (96.1) | 1 (98.0) | 1 (100.0) | 1 | 2 |
| S. marcescens (51) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 2 (3.9) | 15 (33.3) | 30 (92.2) | 3 (98.0) | 1 (100.0) | 0.5 | 0.5 | ||||
| Nonfermentative bacilli (402) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 9 (2.2) | 41 (12.4) | 85 (33.6) | 136 (67.4) | 77 (86.6) | 45 (97.8) | 9 (100.0) | 1 | 4 | ||
| P. aeruginosa (200) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 1 (0.5) | 5 (3.0) | 76 (41.0) | 70 (76.0) | 39 (95.5) | 9 (100.0) | 2 | 4 | ||
| A. baumannii (202) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 9 (4.5) | 40 (24.3) | 80 (63.9) | 60 (93.6) | 7 (97.0) | 6 (100.0) | 0.5 | 1 | |||
a
Includes the following species (no.): Proteus mirabilis (30), Morganella morganii (11), Proteus vulgaris (4), Providencia rettgeri (4), and Providencia stuartii (2).