TABLE 4.
Log10 CFU of M. avium/lung in four strains of mice with and without clarithromycin treatment from week 4 to week 12 postinfection
| Mouse strain and treatment | Mean log10 CFU/lung (SD) by time point postinfection |
|||||||
|---|---|---|---|---|---|---|---|---|
| Day 1 | Wk 1 | Wk 2 | Wk 3 | Wk 4 | Wk 8 | Wk 12 | Wk 23 | |
| BALB/c | ||||||||
| Untreated | 4.92 (0.02) | 5.17 (0.26) | 5.68 (0.10) | 5.32 (0.07) | 7.03 (0.35) | 10.60 (0.82) | 8.79 (0.44) | 6.13 (0.95) |
| Clarithromycin | 7.95 (0.07) | 4.46 (0.15) | ||||||
| C57BL/6 | ||||||||
| Untreated | 4.98 (0.01) | 5.16 (0.13) | 5.72 (0.09) | 6.39 (0.14) | 7.15 (0.15) | 8.61 (0.27) | 8.51 (0.21) | 6.74 (0.18) |
| Clarithromycin | 8.00 (0.01) | 5.69 (0.08) | ||||||
| Beige | ||||||||
| Untreated | 4.88 (0.14) | 5.35 (0.20) | 5.89 (0.02) | 5.77 (0.20) | 7.36 (0.05) | 11.30 (0.01) | 9.30 (0.52) | 7.54 (0.25) |
| Clarithromycin | 7.91 (0.07) | 5.28 (0.44) | ||||||
| Nude | ||||||||
| Untreated | 5.01 (0.06) | 5.34 (0.28) | 5.60 (0.21) | 5.54 (0.16) | 7.26 (0.23) | 11.20 (0.20) | 10.90 (0.41) | 7.40 (0.90) |
| Clarithromycin | 7.89 (0.17) | 6.16 (1.00) | ||||||