TABLE 4.

Evaluation of acute toxicity in mice treated with pYR, cpYR, or neomycin sulfate (positive control)

Dose (mg · kg−1) and effecta	No. of mice (n = 5/group)
	Neomycin sulfate	pYR	cpYR
0
No effect	5	5	5
Toxicity level I	0	0	0
Toxicity level II	0	0	0
5
No effect	5	5	5
Toxicity level I	0	0	0
Toxicity level II	0	0	0
10
No effect	5	5	5
Toxicity level I	0	0	0
Toxicity level II	0	0	0
25
No effect	3	4	5
Toxicity level I	2	1	0
Toxicity level II	0	0	0
50
No effect	2	2	4
Toxicity level I	0	2	1
Toxicity level II	3	1	0
100
No effect	2	1	3
Toxicity level I	0	2	2
Toxicity level II	3	2	0

^aToxicity grading was as follows: level I, narrowing of eyes; level II, crouching and cuddling.