TABLE 2.
Antibiotic susceptibility of 30 Y. pestis strains
| Antibiotic | Broth dilution MIC data at: |
% agreement | Breakpoint % agreement (35°/28°) | |||||
|---|---|---|---|---|---|---|---|---|
| 35°C |
28°C |
|||||||
| Range | MIC50 | MIC90 | Range | MIC50 | MIC90 | |||
| Amikacin | 0.25–4 | 1 | 2 | 0.25–8 | 2 | 8 | 25 | 12.5/50a |
| Gentamicin | 0.06–1 | 0.5 | 1 | 0.06–2 | 1 | 2 | 50 | 25/50b |
| Netilmicin | 0.12–2 | 0.5 | 1 | 0.06–4 | 0.5 | 1 | 100 | 12.5/12.5a |
| Streptomycin | 1–8 | 2 | 4 | 1–16 | 4 | 8 | 50 | 100/50b |
| Tobramycin | 0.06–1 | 0.5 | 1 | 0.06–2 | 0.5 | 1 | 100 | 25/25a |
| Azithromycin | 1–16 | 4 | 8 | 1–64 | 16 | 32 | 25 | |
| Cethromycin | 0.25–4 | 1 | 2 | 1–16 | 4 | 8 | 25 | |
| Telithromycin | 0.5–8 | 2 | 4 | 0.5–32 | 4 | 16 | 25 | |
| Clarithromycin | 16–>64 | 64 | 64 | 4–>64 | 64 | >64 | 100 | |
| Garenoxacin | 0.015–0.06 | 0.06 | 0.06 | 0.004–0.6 | 0.015 | 0.03 | 50 | |
| Ciprofloxacin | 0.008–0.12 | 0.015 | 0.03 | 0.004–0.03 | 0.008 | 0.015 | 50 | 30/1.5b |
| Gatifloxacin | 0.015–0.12 | 0.06 | 0.06 | 0.004–0.06 | 0.03 | 0.03 | 50 | 30/1.5a |
| Gemifloxacin | 0.004–0.03 | 0.015 | 0.03 | 0.002–0.03 | 0.008 | 0.03 | 100 | 12/12a |
| Levofloxacin | 0.008–0.12 | 0.03 | 0.06 | 0.008–0.06 | 0.03 | 0.03 | 50 | 6/3b |
| Moxifloxacin | 0.015–0.06 | 0.03 | 0.06 | 0.008–0.06 | 0.03 | 0.03 | 50 | |
| Nalidixic acid | 0.25–4 | 2 | 4 | 0.5–2 | 1 | 2 | 50 | 25/12.5a |
| Ofloxacin | 0.015–0.25 | 0.06 | 0.12 | 0.008–0.12 | 0.03 | 0.06 | 50 | 6/3a |
| Sparfloxacin | 0.004–0.06 | 0.015 | 0.03 | 0.002–0.03 | 0.008 | 0.015 | 50 | |
| Novobiocin | 8–>64 | 64 | >64 | 8–>64 | 64 | >64 | 100 | |
| Amoxicillin-clavulanate (2:1) | 0.03–1 | 0.25 | 0.5 | 0.06–0.5 | 0.25 | 0.25 | 50 | 6/6a |
| Amoxicillin | 0.03–1 | 0.25 | 0.5 | 0.06–1 | 0.25 | 0.5 | 100 | |
| Ampicillin | 0.03–4 | 0.25 | 0.5 | 0.06–0.5 | 0.25 | 0.5 | 100 | 6/6a |
| Penicillin G | 0.012–1 | 0.25 | 1 | 0.03–2 | 0.5 | 2 | 50 | |
| Piperacillin | 0.03–0.5 | 0.06 | 0.25 | 0.03–0.5 | 0.12 | 0.5 | 50 | 2/3a |
| Imipenem | 0.12–1 | 0.25 | 0.5 | 0.06–1 | 0.25 | 0.5 | 100 | |
| Ertapenem (Invanz) | 0.004–0.06 | 0.03 | 0.03 | 0.002–0.03 | 0.015 | 0.03 | 100 | |
| Faropenem | 0.06–2 | 0.25 | 0.5 | 0.25–1 | 0.5 | 1 | 50 | |
| Meropenem | 0.015–0.12 | 0.06 | 0.12 | 0.015–0.06 | 0.06 | 0.06 | 50 | |
| Cefepime | 0.008–0.06 | 0.03 | 0.06 | 0.03–0.25 | 0.03 | 0.25 | 25 | 1/3a |
| Ceftazidime | 0.03–0.5 | 0.12 | 0.25 | 0.03–0.25 | 0.06 | 0.12 | 50 | 3/1.5a |
| Cefotaxime | 0.004–0.03 | 0.015 | 0.03 | 0.004–0.015 | 0.008 | 0.015 | 50 | 0.4/19a |
| Cefotetan | 0.03–0.5 | 0.25 | 0.5 | 0.03–0.25 | 0.12 | 0.25 | 50 | 3/1.5a |
| Cefuroxime | 0.03–2 | 0.5 | 2 | 0.06–2 | 0.5 | 1 | 50 | 25/12.5a |
| Cefazolin | 0.25–8 | 2 | 4 | 1–4 | 2 | 4 | 50 | 8/25a |
| Ceftriaxone | 0.008–0.03 | 0.015 | 0.03 | 0.008–0.03 | 0.015 | 0.015 | 50 | 0.4/19a |
| Aztreonam | 0.008–0.06 | 0.03 | 0.03 | 0.008–0.03 | 0.015 | 0.03 | 100 | 0.4/38a |
| Sulfamethoxazole | 0.5–>64 | 16 | 64 | 2−>64 | 16 | >64 | 100 | 25/25a |
| Sulfamethoxazole-trimethoprim (19:1) | 0.25–8 | 0.5 | 8 | 0.12–4 | 1 | 4 | 50 | 21/11b |
| Trimethoprim | 0.12–16 | 0.5 | 8 | 0.12–8 | 0.5 | 2 | 25 | 1/25a |
| Doxycycline | 0.06–2 | 0.5 | 1 | 0.06–0.5 | 0.25 | 0.5 | 50 | 25/12.5b |
| Tetracycline | 0.25–2 | 0.5 | 2 | 1–16 | 4 | 8 | 25 | 50/50b |
| Tigecycline | 0.06–0.5 | 0.25 | 0.25 | 0.03–0.5 | 0.12 | 0.5 | 50 | |
| Rifampin | 0.25–4 | 2 | 4 | 1–64 | 2 | 16 | 25 | |
| Chloramphenicol | 0.25–4 | 1 | 4 | 0.5–16 | 4 | 8 | 50 | 50/100b |
| Fusidic acid | 16–>64 | 64 | >64 | 2–>64 | 32 | 64 | 100 | |