Table 2.
Frequency of GPR50 polymorphisms according to depression prevalence and antidepressant use in men and women (N = 1010)
| Depression |
Antidepressant use |
Depression and/or antidepressant use |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| No % (N) | Yes% (N) | (χ2)1 P | No% (N) | Yes% (N) | χ2 (df) P | No, No% (N) | Yes, No% (N) | No, Yes% (N) | Yes, Yes% (N) | χ2 (df) P | |
| Men | |||||||||||
| rs13440581: G | 62.1 (208) | 55.4 (36) | (1.03) | 61.3 (242) | 40 (2) | (0.94) | |||||
| A | 37.9 (127) | 44.6 (29) | 0.31 | 38.7 (153) | 60 (3) | 0.33 | |||||
| rs2072621: C | 58.2 (195) | 61.5 (40) | (0.25) | 58.2 (230) | 100 (5) | (3.56) | |||||
| A | 41.8 (140) | 38.5 (25) | 0.62 | 41.8 (165) | 0 (0) | 0.06 | |||||
| rs561077: A | 60.9 (204) | 60 (39) | (0.02) | 60.8 (240) | 60 (3) | (0.001) | |||||
| G | 39.1 (131) | 40 (26) | 0.89 | 39.2 (115) | 40 (2) | 0.97 | |||||
| Women | |||||||||||
| rs13440581: GG | 33.0 (137) | 27.7 (54) | (9.59) | 32.1 (185) | 17.7 (6) | (10.3) | 33.3 (134) | 29.5 (51) | 25.0 (3) | 13.6 (3) | (12.1) |
| GA | 42.9 (178) | 55.9 (109) | 0.008 | 45.6 (262) | 73.5 (25) | 0.006 | 42.7 (172) | 52.0 (90) | 50.0 (6) | 86.4 (19) | 0.003 |
| AA | 24.1 (100) | 16.4 (32) | 22.4 (129) | 8.8 (3) | 24.1 (97) | 18.5 (32) | 25.0 (3) | 0 (0) | |||
| rs561077: AA | 32.8 (136) | 34.4 (67) | (3.86) | 32.3 (186) | 50.0 (17) | (6.35) | 33.0 (133) | 27.2 (47) | 25.0 (3) | 27.3 (6) | (2.61) |
| GA | 48.9 (203) | 41.5 (81) | 0.15 | 47.7 (275) | 26.5 (9) | 0.04 | 46.2 (186) | 45.7 (79) | 33.3 (4) | 59.1 (13) | 0.27 |
| GG | 18.3 (76) | 24.1 (47) | 20.0 (115) | 23.5 (8) | 20.8 (84) | 27.1 (47) | 41.7 (5) | 13.6 (3) | |||
| rs2072621: CC | 32.8 (136) | 27.2 (53) | (2.42) | 31.3 (80) | 26.5 (9) | (0.36) | 32.3 (130) | 32.4 (56) | 50.0 (6) | 50.0 (11) | (5.98) |
| AC | 45.8 (190) | 47.2 (92) | 0.30 | 46.0 (265) | 50.0 (17) | 0.84 | 49.9 (201) | 42.8 (74) | 16.7 (2) | 31.8 (7) | 0.07 |
| AA | 21.4 (89) | 25.6 (50) | 22.7 (131) | 23.5 (8) | 17.9 (72) | 24.9 (43) | 33.3 (4) | 18.2 (4) | |||
1
Degrees of freedom = one for men (i.e., two group genotypes); two for women (three group genotypes).