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. Author manuscript; available in PMC: 2015 Mar 12.
Published in final edited form as: Nat Biotechnol. 2014 Apr 20;32(5):490–495. doi: 10.1038/nbt.2886

Figure 3. Molecular profiling of ovarian cancer protein markers.

Figure 3

(a) Levels of 71 protein markers were determined in ovarian cancer cell lines and benign cells(including mesothelial origin: LP3 and LP9, benign ovarian origin: TIOSE 4 and TIOSE 6 and blood origin: buffy coat). Clustering analyses based on Pearson correlation categorized all markers into four subgroups, from left to right: 1) cancer markers expressed by ovarian cancer cell lines only, 2) ubiquitous markers present in both cancer and benign cells, 3) benign markers expressed by benign cells only and 4) markers absent in both cell types. a.u., arbitrary unit. (b, c) Putative ovarian cancer markers (EpCAM, CD24, CA19-9, CLDN3, CA-125, MUC18, EGFR, HER2), immune host cell markers (CD41, CD45) and a mesothelial marker (D2-40) were profiled on exosomes (b, using nPLEX sensor) and their parental ovarian cell lines (c, using flow cytometry). MFI, mean fluorescence intensity. a.u., arbitrary unit. All measurements were performed in triplicate and the data is displayed as mean values.

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