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. 2015 Mar 12;5:9043. doi: 10.1038/srep09043

Figure 7. Effect of acute fisetin (Fis) administration on depression-like and anxiety-like behaviors in sham and CCI mice.

Figure 7

Acute fisetin administration started 15 days after CCI surgery. Mice (sham or CCI) were administered with vehicle or fisetin (5, 15 and 45 mg/kg) and challenged in forced swim test (FST, A), novelty suppressed feeding test (NSFT, B) or light-dark test (LDT, C) at different time points (0, 1, 2, 4 and 6 h) after fisetin administration. (A) and (B) Acute fisetin administration (5, 15 and 45 mg/kg) displayed rapid onset antidepressant-like effect in sham rather than CCI mice, evidenced by reduced immobility time in FST (A) and a decrease of latency to feed in NSFT (B). This action is dose dependent and seems to be transitory (lasts for no more than 4 h). (C) In light-dark test, acute fisetin administration (5, 15 and 45 mg/kg) did not show any anxiolytic activity in both sham and CCI mice. Data are expressed as mean ± SEM (n = 9–12 per group), assessed by multifactor ANOVA followed by Duncan test.