Table 1. Effect of chronic fisetin treatment on monoamines (metabolites) in the spinal cord of Sham and CCI mice.
| Concentration (ng/g) | ||||||
|---|---|---|---|---|---|---|
| Group | 5-HT | 5-HIAA | 5-HIAA/5-HT | NA | Dopamine | DOPAC |
| Sham mice | ||||||
| Vehicle | 734.8 ± 31.0 | 362.9 ± 25.4 | 0.49 ± 0.06 | 566.0 ± 21.5 | 73.1 ± 6.6 | 26.7 ± 4.3 |
| Fis-45 mg/kg | 765.4 ± 40.2 | 340.0 ± 21.0 | 0.44 ± 0.07 | 582.9 ± 28.1 | 77.5 ± 5.9 | 23.8 ± 3.8 |
| CCI mice | ||||||
| Vehicle | 447.5 ± 38.6## | 381.1 ± 24.8 | 0.85 ± 0.05## | 531.4 ± 22.8 | 68.4 ± 5.5 | 28.1 ± 3.9 |
| Fis-5 mg/kg | 478.9 ± 34.1 | 393.7 ± 28.6 | 0.82 ± 0.07 | 549.9 ± 18.0 | 72.0 ± 6.7 | 27.2 ± 4.6 |
| Fis-15 mg/kg | 571.3 ± 45.6* | 372.6 ± 19.9 | 0.65 ± 0.06** | 573.4 ± 29.1 | 69.8 ± 4.3 | 23.8 ± 5.4 |
| Fis-45 mg/kg | 694.3 ± 39.8** | 358.4 ± 26.0 | 0.51 ± 0.07** | 590.7 ± 24.3* | 74.3 ± 6.0 | 24.5 ± 4.7 |
Fis: fisetin. Values were expressed as mean ± SEM of 6–9 mice.
##p < 0.01, compared with vehicle treated sham mice.
*p < 0.05 and **p < 0.01, compared with vehicle treated CCI mice.