Table 3.
Patient demographics and wound characteristics
| Total | CCO | Control | p -value | |
|---|---|---|---|---|
| Demographic | (n = 55) | (n = 28) | (n = 27) | ANOVA/Chi-square |
| Age | ||||
| Mean ± SD | 57.9 ± 12.3 | 56.9 ± 12.0 | 59.0 ± 12.7 | 0.54 |
| Minimum, Maximum | 35.0, 97.0 | 35.0, 97.0 | 39.0, 88.0 | |
| Geriatric, n (%) | ||||
| <85 years | 52 (94.5) | 27 (96.4) | 25 (92.6) | 0.53 |
| ≥85 years | 3 (5.5) | 1 (3.6) | 2 (7.4) | |
| Sex, n (%) | ||||
| Men | 41 (74.5) | 21 (75.0) | 20 (74.1) | 0.94 |
| Women | 14 (25.5) | 7 (25.0) | 7 (25.9) | |
| Race, n (%) | ||||
| White/Caucasian | 47 (85.5) | 25 (89.3) | 22 (81.5) | 0.41 |
| Black/African American | 8 (14.5) | 3 (10.7) | 5 (18.5) | |
| Ethnicity, n (%) | ||||
| Hispanic/Latino | 9 (16.4) | 5 (17.9) | 4 (14.8) | 0.76 |
| Non-Hispanic/Latino | 46 (83.6) | 23 (82.1) | 23 (85.2) | |
| Ankle brachial index, n (%) | ||||
| n* | 33 (60.0%) | 16 (57.1) | 17 (63.0) | 0.52 |
| Mean ± SD | 1.0 ± 0.1 | 1.0 ± 0.1 | 1.0 ± 0.1 | |
| Minimum, Maximum | 0.8, 1.1 | 0.8, 1.1 | 0.8, 1.1 | |
| Wound area (cm 2 ) | ||||
| Mean ± SD | 1.9 ± 1.4 | 2.0 ± 1.1 | 1.8 ± 1.6 | 0.73 |
| Minimum, Maximum | 0.1, 7.5 | 0.1, 4.6 | 0.2, 7.5 | |
| Wound location, n (%) | ||||
| Distal | 2 (3.6) | 1 (3.6) | 1 (3.7) | 0.38 |
| Lateral | 3 (5.5) | 2 (7.1) | 1 (3.7) | |
| Lateral/dorsal/distal | 1 (1.8) | 0 (0.0) | 1 (3.7) | |
| Plantar | 43 (78.2) | 20 (71.4) | 23 (85.2) | |
| Plantar/medial | 6 (10.9) | 5 (17.9) | 1 (3.7) | |
| Wound side, n (%) | ||||
| Left foot | 31 (56.4) | 14 (50.0) | 17 (63.0) | 0.33 |
| Right foot | 24 (43.6) | 14 (50.0) | 10 (37.0) | |
| Number of sharp debridements | ||||
| 6 Treatment weeks | ||||
| Mean ± SD | 4.05 ± 1.83 | 4.07 ± 1.88 | 4.04 ± 1.81 | 0.45 |
| Minimum, Maximum | 1.0, 6.0 | 1.0, 6.0 | 1.0, 6.0 | |
| 6 Follow-up treatments | ||||
| N | 39 (70.9%) | 20 (71.4%) | 19 (70.4%) | |
| Mean ± SD | 3.11 ± 2.32 | 3.32 ± 2.24 | 2.89 ± 2.45 | 0.81 |
| Minimum, Maximum | 0.0, 6.0 | 0.0, 6.0 | 0.0, 6.0 |
ANOVA, analysis of variance; CCO, clostridial collagenase ointment; SD, standard deviation.
*Not all patients had an ankle brachial index assessment.