Figure 3.

Decreased proportions of circulating HLA-DR ⁻ CD33 ⁺ CD11b ⁺ MDSCs and CD4 ⁺ CD25 ^high FOXP3 ⁺ Treg cells in CRC patients after tumor resection. PBMCs were isolated from 26 CRC patients before and after surgery. (A-D) Representative density plots of circulating HLA-DR⁻CD33⁺CD11b⁺ MDSCs, CD4⁺CD25^highFOXP3⁺ Tregs, CD3⁺CD4⁺ T cells, CD3⁺CD8⁺ T cells, and CD3⁻CD16⁺ NK cells from one CRC patient before and after surgery are shown. (E-H) The graph shows that the proportions of circulating MDSCs and Tregs were significantly decreased after surgery (P < 0.05), whereas the proportions of CD3⁺CD4⁺ T cells, CD3⁺CD8⁺T cells, and CD3⁻CD16⁺ NK cells were not significantly different after the operation (P > 0.05).