Table 1.
Effect of arsenic trioxide (ATO) and/or lutein (LU) administration on indices related to hepatotoxicity in mice.
| Control (NS) | ATO (4 mg/kg) | LU (40 mg/Kg) | ATO + LU (4 mg/kg + 40 mg/Kg) | |
|---|---|---|---|---|
| Initial body weight (g) | 19.41 ± 1.16 | 19.31 ± 1.69 | 21.12 ± 1.43 | 20.50 ± 1.59 |
| Final body weight (g) | 34.68 ± 2.03 | 34.82 ± 1.19ac | 25.83 ± 1.96 | 30.37 ± 1.91ab |
| Body weight gain (g) | 15.27 ± 2.65 | 15.52 ± 1.71 | 4.71 ± 2.68 | 9.88 ± 1.93 |
| Liver weight (g) | 1.38 ± 0.17 | 3.23 ± 0.15ab | 1.05 ± 0.07a | 1.16 ± 0.26ab |
| Liver index (%) | 3.99 ± 0.61 | 9.29 ± 0.47b | 4.1 ± 0.49a | 3.88 ± 0.96b |
| AST (U/g prot) | 22.01 ± 4.95 | 31.62 ± 7.28b | 17.77 ± 4.97a | 10.87 ± 4.94ab |
| ALT (U/g prot) | 78.34 ± 21.40 | 136.51 ± 29.31b | 68.84 ± 17.25a | 59.98 ± 17.08b |
Note: the results were described as mean ± SD (n = 10). aIndicating significant difference from control (NS) group at P < 0.01; bindicating significant difference from the ATO group (4 mg/kg) at P < 0.01; cindicating significant difference from the ATO + LU group (4 mg/kg + 40 mg/Kg) at P < 0.01.