Table 2.
hCAP18 and mineral metabolite/hormone levels on ICU days 1 and 3
| Biomarker | Reference range | ICU day 1 (N = 121) | ICU day 3 (N = 111) † | P value |
|---|---|---|---|---|
| hCAP18 (ng/ml) | Undefined | 160 (106-286) | 166 (116-291) | 0.92 |
| Total 25D (ng/ml) | 30-80 | 17 (13-22) | 17 (14-21) | 0.42 |
| Bioavailable 25D (ng/ml) | Undefined | 2.5 (1.8-3.5) | 2.4 (1.6-3.3) | 0.24 |
| Free 25D (pg/ml) | Undefined | 9.6 (6.5-12.9) | 9.5 (6.5-12.9) | 0.98 |
| DBP (mg/dl) | 20-55 | 12.7 (9.4-17.1) | 13.7 (10.1-17.1) | 0.27 |
| Albumin (g/dl) | 4.1-5.3 | 3.1 (2.4-3.5) | 2.9 (2.3-3.3) | 0.002 |
| PTH (pg/ml) | 15-65 | 40 (28-56) | --- | N/A |
Values represent median (25th to 75th interquartile range). †Fewer samples were available on ICU day 3 due to interim death or discharge. ICU, intensive care unit; hCAP18, human cathelicidin antimicrobial protein-18; 25D, 25-hydroxyvitamin D; DBP, D-binding protein; PTH, parathyroid hormone.