Table 2. Significant fibrinogen cluster gene-gene interactions in NHANES III for plasma fibrinogen.
Using multivariate linear regression, we added cross product terms (all pair-wise SNP-SNP) to the regression models for plasma fibrinogen. Below are the association results for each SNP individually as well as the association results for the interaction term.
| Gene-Gene Interactions |
SNP-SNP Interactions | SNP 1 Effect | SNP 2 Effect | Interaction Term |
|||
|---|---|---|---|---|---|---|---|
| Beta (SE) |
P | Beta (SE) |
P | Beta (SE) |
P | ||
| Non-Hispanic Blacks | |||||||
| FGB × FGG | rs1800791 × rs1800792 | −0.08 (0.04) | 0.07 | −0.01 (0.04) | 0.71 | 0.20 (0.08) | 0.02 |
| FGA × FGB | rs2070006 × rs2227395 | 0.01 (0.03) | 0.85 | <0.00 1.00 (0.03) | 0.94 | 0.14(0.07) | 0.04 |
| FGA × FGB | rs2070009 × rs2227395 | <0.001 (0.03) | 0.94 | <0.00 1.00 (0.03) | 0.94 | −0.16 (0.07) | 0.02 |
| FGA × FGG | rs2070022 × rs1049636 | −0.08 (0.04) | 0.06 | 0.06 (0.03) | 0.07 | −0.18 (0.08) | 0.03 |
| FGB × FGG | rs2227395 × rs2066861 | 1.00 (0.03) | 0.94 | 0.05 (0.03) | 0.12 | 0.17 (0.07) | 0.01 |
| FGA × FGB | rs6050 × rs2227395 | 0.02 (0.03) | 0.52 | <0.00 1.00 (0.03) | 0.94 | −0.15 (0.06) | 0.02 |
| Non-Hispanic Whites | |||||||
| FGB × FGB | rs1800791 × rs2227395 | <0.001 (0.03) | 0.89 | −0.08 (0.02) | 6.7E-4 | 0.15 (0.06) | 0.02 |
| FGA × FGB | rs2070006 × rs2227395 | 0.02 (0.02) | 0.20 | −0.08 (0.02) | 6.7E-4 | −0.09 (0.03) | 0.005 |
| FGA × FGB | rs2070006 × rs4220 | 0.02 (0.02) | 0.20 | −0.09 (0.02) | 2.1E-3 | −0.09 (0.04) | 0.01 |
| FGA × FGB | rs2070009 × rs2227395 | −0.03 (0.02) | 0.16 | −0.08 (0.02) | 6.7E-4 | 0.09 (0.04) | 0.005 |
| FGA × FGB | rs2070009 × rs4220 | −0.03 (0.02) | 0.16 | −0.09 (0.02) | 2.1E-3 | 0.09 (0.04) | 0.01 |
| FGA × FGB | rs2070011 × rs2227395 | 0.03 (0.02) | 0.14 | −0.08 (0.02) | 6.7E-4 | −0.08 (0.04) | 0.03 |
| FGA × FGB | rs2070011 × rs4220 | 0.03 (0.02) | 0.14 | −0.09 (0.02) | 2.1E-3 | −0.09 (0.04) | 0.01 |
| FGA × FGB | rs2070022 × rs2227395 | −0.03 (0.02) | 0.23 | −0.08 (0.02) | 6.7E-4 | 0.18 (0.06) | 0.002 |
| FGA × FGB | rs2070022 × rs4220 | −0.03 (0.02) | 0.23 | −0.09 (0.02) | 2.1E-3 | 0.14 (0.06) | 0.02 |
| FGB × FGG | rs2227395 × rs2066861 | −0.08 (0.02) | 6.7 E-4 | 0.05 (0.02) | 0.01 | −0.13 (0.04) | 0.002 |
| FGB × FGG | rs4220 × rs2066861 | −0.09 (0.02) | 2.1 E-3 | −0.03 (0.02) | 0.23 | −0.08 (0.04) | 0.05 |
| FGA × FGB | rs6050 × rs2227395 | −0.04 (0.02) | 0.04 | −0.08 (0.02) | 6.7E-4 | 0.13 (0.04) | 0.001 |
| FGA × FGB | rs6050 × rs4220 | −0.04 (0.02) | 0.04 | −0.09 (0.02) | 2.1E-3 | 0.09 (0.04) | 0.02 |
| Mexican Americans | |||||||
| FGA × FGB | rs2070008 × rs1800791 | −0.02 (0.04) | 0.57 | −0.03 (0.03) | 0.26 | 0.18 (0.08) | 0.022 |
| FGA × FGG | rs2070033 × rs1049636 | −0.16 (0.15) | 0.26 | 0.04 (0.03) | 0.08 | 0.59 (0.30) | 0.051 |
| FGA × FGB | rs2070033 × rs1800791 | −0.16 (0.15) | 0.26 | −0.03 (0.03) | 0.26 | −0.66 (0.33) | 0.048 |
| FGB × FGG | rs2227395 × rs1049636 | −0.02 (0.04) | 0.58 | 0.04 (0.03) | 0.08 | 0.17 (0.06) | 0.006 |
| FGB × FGG | rs2227395 × rs1800792 | −0.02 (0.04) | 0.58 | −0.03 (0.03) | 0.36 | −0.13 (0.06) | 0.025 |
| FGB × FGG | rs4220 × rs1049636 | −0.04 (0.04) | 0.36 | 0.04 (0.03) | 0.08 | 0.14 (0.07) | 0.035 |
| FGB × FGG | rs4220 × rs1800792 | −0.04 (0.04) | 0.36 | −0.03 (0.03) | 0.36 | −0.12 (0.06) | 0.032 |
Abbreviations: SE = standard error.