Table 3. Gene-environment interactions with fibrinogen variants and age, sex, BMI, and smoking status.

Using linear regression we added the multiplicative terms (SNP × environmental factor) to the regression model while simultaneously adjusting for covariates: age, sex, BMI, and smoking status. Below are the association results for the single SNP or environmental factor tests of association as well as the association results for the interaction term. Suppressed = results not released by CDC because counts were < 5 (see ‘Statistical Methods’).

		SNP Effect		Environment Effect		Interaction Effect
Interaction	Gene	Beta (SE)	P	Beta (SE)	P	Beta (SE)	P
Non-Hispanic Blacks
rs2227434 × age	FGB	0.26 (0.49)	0.59	0.008 (0.002)	3.76E-07	0.004 (<0.01)	3.76E-07
rs2227434 × BMI	FGB	0.26 (0.49)	0.59	0.02 (0.003)	4.32E-06	0.01 (<0.01)	4.32E-06
rs6050 × BMI	FGA	0.01 (0.03)	0.52	0.01 (0.003)	5.87E-06	0.01 (0.05)	8.10E-03
rs2227434 × sex	FGB	0.26 (0.49)	0.59	0.09 (0.04)	0.02	0.05 (0.02)	0.02
rs6058 × sex	FGB	0.06 (0.05)	0.18	0.10 (0.04)	0.01	0.22 (0.10)	0.03
rs2070033 × smoking	FGA	0.07 (0.05)	0.16	−0.06 (0.04)	0.14	−0.22 (0.10)	0.03
rs2070006 × BMI	FGA	0.005 (0.03)	0.85	0.02 (0.003)	6.94E-06	−0.01 (<0.01)	0.03
rs2070008 × smoking	FGA	−0.01 (0.04)	0.75	−0.05 (0.04)	−0.16	−0.19 (0.01)	0.04
Non-Hispanic Whites
rs2070017 × sex	FGA	0.24 (0.22)	0.28	0.07 (0.03)	0.01	0.03	0.01
rs2066861 × sex	FGG	0.05 (0.02)	0.01	0.06 (0.03)	0.02	−0.08	0.05
rs2070009 × sex	FGA	−0.03 (0.02)	0.16	0.06 (0.03)	0.02	0.07	0.05
rs6050 × sex	FGA	−0.04 (0.02)	0.04	0.06 (0.03)	0.04	0.08	0.05
Mexican Americans
rs2066879 × BMI	FGG	−0.37 (0.24)	0.12	0.02 (0.004)	3.1E-5	−0.28	0.03