Table 1.
Comparison of 12-Month Bone Mineral Density and Biochemical Changes in Men Receiving Alendronate, in Postmenopausal Women Receiving Alendronate, and Between Groupsa
| Factor | Group 1: men (N = 9)
|
Group 2: postmenopausal women (N = 24)
|
Comparison between groups (N = 33): absolute difference
|
Reference range | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Baseline | 12 mo | Change: % (value) | P value | Baseline | 12 mo | Change:% (value) | P value | % | P value | ||
| Bone mineral density | |||||||||||
| Lumbar spine (g/cm2) | 0.802 | 0.838 | 4.41 (0.035) | .009 | 0.799 | 0.835 | 4.54 (0.036) | <.001 | −0.1 | .941 | … |
| Total hip (g/cm2) | 0.736 | 0.758 | 2.95 (0.022) | .027 | 0.686 | 0.707 | 3.04 (0.021) | <.001 | −0.1 | .932 | … |
| Distal radius (g/cm2) | 0.625 | 0.639 | 2.13 (0.013) | .194 | 0.500 | 0.501 | 0.18 (0.001) | .727 | 1.9 | .089 | … |
| Bone-specific alkaline phosphatase (μg/L) | 29.43 | 15.71 | −46.60 (−13.71) | .003 | 34.29 | 19.01 | −44.55 (−15.27) | <.001 | −2.1 | .753 | b |
| NTX (BCE nmol/mmol creatinine) | 60.14 | 23.71 | −60.57 (−36.43) | .071 | 99.56 | 52.94 | −46.82 (−46.61) | .109 | −13.8 | .826 | <85 |
| Serum parathyroid hormone (pmol/L) | 20.36 | 27.50 | 35.09 (7.14) | .062 | 15.30 | 13.87 | −9.37 (−1.43) | .285 | 44.5 | .006 | 1.3–7.6 |
| 1,25(OH)2D (pmol/L) | 133.29 | 162.86 | 22.19 (29.57) | .122 | 130.05 | 122.52 | −5.79 (−7.52) | .430 | 28.0 | .059 | 40–140 |
| 25(OH)D (nmol/L) | 40.57 | 48.57 | 19.72 (8.00) | .086 | 48.67 | 51.05 | 4.89 (2.38) | .461 | 14.8 | .354 | c |
| Urinary calcium (mmol/d) | 5.76 | 4.88 | −15.28 (−0.88) | .228 | 4.79 | 4.06 | −15.34 (−0.73) | .018 | 0.1 | .815 | 1.2–6.2 |
| Total calcium (mmol/L) | 2.66 | 2.57 | −3.36 (−0.09) | .072 | 2.66 | 2.62 | −1.48 (−0.04) | .188 | −1.9 | .371 | 2.2–2.6 |
| Ionized calcium (mmol/L) | 1.39 | 1.33 | −4.09 (−0.06) | .230 | 1.32 | 1.36 | 2.61 (0.03) | .375 | −6.7 | .166 | 1.17–1.33 |
| Phosphate (mmol/L) | 1.13 | 1.00 | −11.56 (−0.13) | .050 | 1.32 | 1.28 | −2.94 (−0.04) | .350 | −8.6 | .221 | 0.90–1.45 |
a
BCE = bone collagen equivalents; NTX = N-terminal telopeptide of cross-linked collagen type I; 1,25(OH)2D = 1,25-dihydroxyvitamin D; 25(OH)D = 25- hydroxyvitamin D.
b
Women >45 years old, postmenopausal: 14.2–42.7; men >25 years old: 15.0–41.3.
c
<25 deficient, <50 insufficient, >250 toxic.