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. 2015 Mar 12;9:80. doi: 10.3389/fncel.2015.00080

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Copyright © 2015 Schwerk, Tenenbaum, Kim and Schroten.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution and reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Pathologic findings in the CP of human patients with meningococcal disease. An immunohistochemical examination (left panel) shows abundant bacteria and bacterial antigens in the lumen of a thrombosed blood vessel and in the interstitial tissue. One N. meningitidis organism (M) can be seen in the surface of a CP epithelial cells. Transmission electron microscopy (right panel) demonstrates meningococci (M) in the interstitial space. The blood vessel wall (VW), a red blood cell (RBC) and the space containing cerebrospinal fluid (CSF) are pointed out. The pictures are reproduced with friendly permission from Guarner et al. (2004).