Table 3.
Multivariate logistic regression of factors associated with mortality
| Adjusted hazard ratio (95% CI) (N=523) * |
p-value | Adjusted hazard ratioin subset with CD4<100 cells/µL (95% CI) (N=170) * |
p-value | |
|---|---|---|---|---|
| Male sex (ref: female) | 2.36 (1.13 – 4.93) | 0.022 | 1.91 (0.69 – 5.32) | 0.215 |
| Age, years | 1.00 (0.97 – 1.04) | 0.866 | 1.02 (0.97 – 1.07) | 0.407 |
| Baseline CD4 count, | ||||
| ≥200 cells/µL | Reference | - | - | |
| 150–199 cells/µL | 0.51 (0.14 – 1.84) | 0.301 | - | - |
| 100–149 cells/µL | 1.08 (0.32 – 3.58) | 0.901 | - | - |
| 50–99 cells/µL | 0.93 (0.27 – 3.20) | 0.902 | Reference | - |
| <50 cells/µL | 1.53 (0.54 – 4.30) | 0.420 | 1.65 (0.57 – 4.77) | 0.358 |
| Baseline Hb, mg/dL (ref: >10) | Reference | - | Reference | - |
| ≤10 | 12.84 (2.15 – 76.71) | 0.005 | 1.13 (0.08 – 15.76) | 0.929 |
| Baseline BMI, kg/m2 (ref: >18.5) | Reference | - | Reference | - |
| 15.6–18.5 | 2.22 (0.98 – 5.02) | 0.056 | 2.28 (0.73 – 7.10) | 0.157 |
| ≤15.5 | 3.99 (1.44 – 11.00) | 0.008 | 5.69 (1.44– 22.48) | 0.013 |
| Tuberculosis infection | 3.39 (1.54 – 7.48) | 0.002 | 2.77 (0.97 – 7.94) | 0.057 |
| Positive serum CrAg | - | - | 4.50 (1.18 – 17.16) | 0.028 |
*
Number of subjects reduced from 540 to 523, and in the smaller cohort of participants with CD4≤ 100 cells/µL from 177 to 170, due to missing BMI data
CI=confidence interval; CrAg=serum cryptococcal antigen; Hb=hemoglobin; BMI=body mass index, kg=kilogram, m=meter, N=number