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. Author manuscript; available in PMC: 2016 Mar 1.
Published in final edited form as: Trends Pharmacol Sci. 2015 Feb 18;36(3):145–152. doi: 10.1016/j.tips.2015.01.002

Figure 4. The GPCR heterotetramer.

Figure 4

1. Constituted by two GPCR homodimers, R1 and R2, pre-coupled to one Gs and one Gi protein, respectively. 2. Gs and Gi coupled the GPCR heterotetramer can simultaneously couple to the C2 and C1 catalytic domains of AC, respectively, providing the frame for the canonical Gs-Gi interaction at the AC level. 3. Additional proteins, such as neuronal calcium binding proteins (in black), bind and modulate the Gs-Gi interaction in the heterotetramer (see text).