Fig 1. Firing patterns of four different types of hNPCs.

Whole-cell current-clamp responses to injection of depolarizing (300 ms, +250 pA) and hyperpolarizing (300 ms, −250 pA) current pulses. Depolarizing current induced firing activity with different frequencies and patterns in 4 subtypes of hNPCs. In response to depolarizing current, PV-ir cells fired at high frequency without any adaptation (A); CR-ir cells fired with an irregular firing pattern (B); SS-ir cells fired at lower frequency with adaptation (C), and pyramidal neurons fired at the lowest frequency with obvious adaptation. The calibration bar in D also applies to A, B and C.