Table 1. Intrinsic membrane properties and synaptic currents of different types of neurons.
| PV | CR | SS | Pyramids | |||||
|---|---|---|---|---|---|---|---|---|
| GFP | Host | GFP | Host | GFP | Host | GFP | Host | |
| Membrane properties | ||||||||
| Rest potential (mV) | -73.7±1.2 | -74.2±1.5 | -70.4±1.4 | -71.1±1.5 | -74.5±1.6 | -73.7±1.4 | -74.9±1.5 | -75.3±1.7 |
| AP threshold (mV) | -48.4±0.9 | -47.6±1.1 | -51.5±1.7 | -49.8±1.5 | -47.9±1.1 | -48.3±1.2 | -51.6±1.3 | -50.2±1.2 |
| AP amplitude (mV) | 71.3±1.0 | 72.4±1.3 | 54.1±2.0 | 56.9±1.7 | 69.9±1.4 | 70.7±1.6 | 69.5±1.1 | 70.3±1.4 |
| AP half-width (msec) | 0.45±0.03 | 0.43±0.05 | 0.86±0.10 | 0.81±0.12 | 0.64±0.08 | 0.62±0.06 | 1.22±0.09 | 1.19±0.10 |
| Rinput (MΩ) | 170.5±13.4 | 165.1±14.8 | 275.6±29.3 | 281.4±31.5 | 183.2±21.2 | 179.9±20.6 | 194.5±15.5 | 183.3±14.7 |
| Time constant (msec) | 14.4±1.2 | 13.8±1.5 | 19.7±1.8 | 18.6±2.1 | 15.8±1.7 | 15.3±1.9 | 19.1±1.3 | 19.3±1.4 |
| f-I slope (Hz/nA) | 324.4±14.5 | 338.5±15.5 | 142.4±16.1 | 149.6±17.5 | 101.2±12.4 | 108.7±13.7 | 54.8±7.9 | 59.5±7.3 |
| AP adaptation | 0.97±0.07 | 0.99±0.08 | 5.63±0.85 | 5.48±0.91 | 2.74±0.47 | 2.63±0.40 | 2.13±0.24 | 2.05±0.22 |
| N | 25 | 11 | 12 | 10 | 13 | 11 | 11 | 12 |
| sEPSCs | ||||||||
| Frequency (Hz) | 9.03±0.55 | 9.34±0.73 | 2.31±0.14 | 2.40±0.18 | 3.49±0.30 | 3.68±0.37 | 6.08±0.42 | 5.47±0.53 |
| Amplitude (pA) | 34.6±1.5 | 31.7±2.2 | 24.0±1.8 | 24.6±2.1 | 25.8±1.7 | 26.2±2.1 | 31.9±2.4 | 30.7±2.2 |
| Rise time (msec) | 1.42±0.09 | 1.21±0.10 | 1.47±0.11 | 1.27±0.12 | 1.40±0.07 | 1.22±0.09 | 1.67±0.12 | 1.55±0.16 |
| τ(msec) | 9.56±0.71 | 8.58±0.82 | 9.67±0.80 | 8.34±0.85 | 9.09±0.85 | 8.54±0.83 | 10.25±0.82 | 9.18±0.97 |
| N | 13 | 5 | 6 | 5 | 6 | 6 | 5 | 6 |
| sIPSCs | ||||||||
| Frequency (Hz) | 7.64±0.48 | 6.69±0.57 | 2.64±0.21 | 2.77±0.23 | 2.77±0.19 | 2.96±0.25 | 13.12±1.14 | 12.78±1.18 |
| Amplitude (pA) | 32.2±2.1 | 28.9±2.5 | 23.6±1.8 | 24.4±2.2 | 24.9±1.7 | 25.1±2.0 | 36.4±2.6 | 34.7±2.8 |
| Rise time (msec) | 1.82±0.10 | 2.14±0.16 | 1.77±0.12 | 1.91±0.18 | 1.85±0.14 | 2.08±0.15 | 1.93±0.14 | 1.99±0.17 |
| τ(msec) | 14.27±1.02 | 16.74±1.42 | 14.06±1.13 | 16.75±1.44 | 14.94±1.16 | 16.65±1.34 | 13.47±0.80 | 12.97±1.16 |
| N | 12 | 6 | 6 | 5 | 7 | 5 | 6 | 6 |
PV, CR and SS are PV-, CR-, and SS-ir interneurons, respectively; AP, action potential; Rinput, input resistance; f-I slope, slope of the relationship between injected current intensity and firing rate;τ, decay time constant; rise time, 10–90% rise time.