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Genealogy of penicillin production strains of P. chrysogenum. Dashed lines indicate conventional mutagenesis during strain improvement programs. Matings (×) of low-penicillin producer Q176 with wild-type Pc3 were performed, and ascospore isolate AS25 was obtained (Böhm et al., 2013). AS25 was further crossed with the industrial high-penicillin production strain P2niaD18. The MAT locus of each strain is indicated by blue for MAT1-1 or red for MAT1-2.
