Table 2. Breast tumor characteristics of CCSS cases included in this study.

Subject	Age at BC	Type BC	Histology	Grade a	ER	Ki-67
CCSS1	27	Invasive	Ductal	UNK	Negative	High
CCSS2	39	Invasive	Ductal	Intermediate	Positive	Low
CCSS3	38	Invasive	Ductal	High	Negative	High
CCSS4	35	In Situ	DCIS+LCIS	Low	Positive	Low
CCSS5	38	Invasive	Ductal	High	Negative	High
CCSS6	39	Invasive	Ductal	Intermediate	Positive	High
CCSS7	30	Invasive	Ductal	High	Positive	High
CCSS8	31	Invasive	Ductal	Low	Positive	Low
CCSS9	49	Invasive	Invasive locular+DCIS	UNK	Positive	High
CCSS10	39	In Situ	DCIS	High	Positive	Low
CCSS11	38	Invasive	Ductal	High	ND	High
CCSS12	44	Invasive	Ductal	High	Negative	High
CCSS13	36	Invasive	Ductal	Intermediate	Positive	High
CCSS14	45	Invasive	Ductal	High	Negative	High
CCSS15	36	Invasive	Lobular	Intermediate	Positive	High
CCSS16	38	Invasive	Ductal	Intermediate	Positive	ND
CCSS17	37	In Situ	DCIS	Intermediate	Positive	High
CCSS18	42	Invasive	Ductal	High	Negative	High
CCSS19	40	Invasive	Ductal	High	Positive	High
CCSS20	48	Invasive	Ductal	High	Positive	High
CCSS21	40	Invasive	Ductal	High	Positive	High
CCSS22	42	Invasive	Ductal	Intermediate	Negative	High
CCSS23	42	Invasive	Ductal	Intermediate	Positive	ND
CCSS24	40	In Situ	DCIS	High	ND	ND
CCSS25	37	Invasive	Ductal	UNK	ND	ND
CCSS26	42	Invasive	Ductal	Intermediate	Positive	ND
CCSS27	40	Invasive	Ductal	High	Negative	ND
CCSS28	48	Invasive	Ductal	Low	Positive	ND
CCSS29	40	Invasive	Ductal	UNK	Positive	ND
CCSS30	42	Invasive	Ductal	Low	Positive	Low
CCSS31	42	Invasive	Ductal	UNK	ND	ND
CCSS32	37	Invasive	Ductal	High	Negative	ND

Abbreviations: BC = breast cancer, DCIS = ductal cell in situ, ER = estrogen receptor, ND = not determined, UNK = unknown.

^aGrade: low = well differentiated or grade I, intermediate = moderately differentiated or grade II, high = poorly differentiated or grade III.