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. Author manuscript; available in PMC: 2015 Mar 12.
Published in final edited form as: Obesity (Silver Spring). 2009 Jan 15;17(4):729–736. doi: 10.1038/oby.2008.593

Figure 4.

Figure 4

Interaction between rs11705701 and percent body fat on DI. (a) Age- and gender-adjusted mean DI and standard deviation stratified by rs11705701 genotype assuming an additive genetic model and percent body fat tertiles. There was a marginal effect of rs11705701 on DI (Bonferroni 2-df P = 0.072), and the interaction between rs11705701 and percent body fat was significantly associated with DI (Bonferroni P = 0.037). Within each genotype group, DI is lower as body fat increases, but the fall in DI is higher among AA homozygotes compared to GG homozygotes. (b) Interaction based on the model parameter estimates and covering the range of percent body fat observed in the BetaGene study. The consequence of the differential effect of the variant across the range of body fat is clearly depicted where in the low body fat range DI is higher with each copy of the A allele, whereas within the high body fat range DI is lower with each additional copy of the A allele. DI, disposition index.