Table 1. Subject Characteristics.
GDM probands | Siblings | Cousins | |
---|---|---|---|
Male/female | 0/118 | 150/229 | 95/125 |
Age (years) | 35.8 (5.8) | 35.1 (8.7) | 33.0 (9.2)*,** |
BMI (kg/m2) | 32.5 (7.0) | 29.9 (6.1)* | 28.6 (6.4)*,** |
Body fat (%) | 39.2 (5.3) | 32.8 (8.5)* | 30.9 (8.6)*,** |
Fasting glucose (mmol/l) | 5.4 (0.6) | 5.2 (0.5)* | 5.1 (0.6)* |
Two-hour glucose (mmol/l) | 9.2 (2.3) | 7.7 (2.2)* | 6.9 (2.0)*,** |
Fasting insulin (pmol/l) | 83 (57) | 62 (45)* | 59 (52)* |
30′ Insulin (pmol/l) | 500 (322) | 524 (346) | 549 (368) |
Two-hour insulin (pmol/l) | 721 (500) | 526 (411)* | 451 (385)*,** |
SG (×10-2 min-1) | 1.48 (0.48) | 1.71 (0.68)* | 1.83 (0.71)*,** |
SI (×10-3 min-1 per pmol/l) | 2.76 (1.76) | 2.94 (1.63) | 3.16 (1.73)* |
AIR (pmol/l × 10 min) | 4171 (4281) | 5678 (4521)* | 6245 (5285)* |
Disposition index | 8694 (5829) | 14055 (9579)* | 15710 (9394)*,** |
Values are unadjusted median and interquartile range.
AIR, acute insulin response; GDM, gestational diabetes mellitus; SG, glucose effectiveness; SI, insulin sensitivity.
Uncorrected P < 0.05 vs. probands.
Uncorrected P < 0.05 vs. siblings.