. Author manuscript; available in PMC: 2015 Mar 12.

Published in final edited form as: Obesity (Silver Spring). 2009 Jan 15;17(4):729–736. doi: 10.1038/oby.2008.593

Table 3. Results of univariate tests of association between SNPs in IGF2BP2 and T2DM-related quantitative traits.

	rs13060777			rs6444082			rs11705701			AG combination^a

	Uncorrected P value			Uncorrected P value			Uncorrected P value			Uncorrected P value

	Effect^b	Age, sex	Age, sex, % fat	Effect^b	Age, sex	Age, sex, % fat	Effect^b	Age, sex	Age, sex, % fat	Effect^b	Age, sex	Age, sex, % fat
BMI	-	0.783	N/A	-	0.124	N/A	-	0.309	N/A	+	0.244	N/A
% Body fat	-	0.134	N/A	-	0.016	N/A	-	0.001	N/A	+	0.011	N/A
Fasting glucose	-	0.422	0.736	-	0.677	0.885	-	0.720	0.664	+	0.645	0.813
Two-hour glucose	+	0.963	0.850	+	0.386	0.942	+	0.225	0.834	-	0.418	0.862
Fasting insulin	-	0.530	0.940	-	0.186	0.774	+	0.352	0.479	+	0.386	0.483
30′ ΔInsulin	+	0.125	0.311	+	0.040	0.137	+	0.018	0.109	-	0.035	0.141
Two-hour insulin	-	0.055	0.104	-	0.014	0.175	-	0.008	0.126	+	0.011	0.156
S_G	+	0.660	0.850	+	0.926	0.790	-	0.256	0.100	-	0.922	0.722
S_I	+	0.718	0.595	+	0.090	0.967	+	0.150	0.743	-	0.166	0.703
AIR	-	0.199	0.396	-	0.051	0.249	-	0.047	0.191	+	0.093	0.337
DI	-	0.154	0.135	-	0.340	0.182	-	0.200	0.065	+	0.361	0.169

Uncorrected P values are shown for test of association under an additive genetic model adjusted for age and sex or with the additional adjustment for percent body fat. AIR, acute insulin response; DI, disposition index; IGF2BP2, insulin-like growth factor-2 binding protein 2; N/A, not available; S_I, insulin sensitivity; SNP, single-nucleotide polymorphism; T2DM, type 2 diabetes mellitus.

The AG combination of rs13060777 and rs6444082 was modeled as the number of copies of the AG haplotype (see Methods and Procedures for details).

The directional effect of the minor allele on the quantitative trait based on the regression coefficient.