Table 3.
Risk of bias assessment for each trial of varenicline using Cochrane risk of assessment of bias tool
| Study | Random sequence generation | Allocation concealment used | Blinding | Incomplete outcome data | Selective reporting | Other bias | |
|---|---|---|---|---|---|---|---|
| Participants and personnel | Outcome assessment | ||||||
| Anthenelli 201324 | Low | Low | Low | Low | Low | Low | Low |
| Bolliger 201125 | Low | Low | Low | Low | Low | Low | Low |
| Brandon 201126 | Low | Low | Low | Low | Low | Low | Low |
| Burstein 200627 | Low | Low | Low | Low | Low | Low | Low |
| Chengappa 201466 | Low | Low | Low | Low | Low | Low | Low |
| Cinciripini 201328 | Low | Low | Low | Low | Low | Low | Low |
| Ebbert 201129 | Low | Unclear | Low | Low | Low | Low | Low |
| Evins 201430 | Low | Low | Low | Low | Low | Low | Low |
| Faessel 200931 | Low | Low | Low | Low | Low | Low | Low |
| Fagerstrom 201032 | Low | Low | Low | Low | Low | Low | Low |
| Fatemi 201333 | Unclear | Low | Low | Low | Low | Low | Low |
| Garza 201134 | Unclear | Low | Low | Low | Low | Low | Low |
| Gonzales 206635 | Low | Low | Low | Low | Low | Low | Low |
| Gonzales 201467 | Low | Low | Low | Low | Low | Low | Low |
| Hughes 201136 | Low | Low | Low | Low | Low | Unclear | Low |
| Jorenby 200637 | Low | Low | Low | Low | Low | Low | Low |
| Litten 201338 | Low | Low | Low | Low | Low | Low | Low |
| McClure 201339 | Low | Low | Low | Low | Low | Low | Low |
| McKee 200940 | Unclear | Unclear | Low | Unclear | Low | Low | Low |
| Meszaros 201341 | Low | Low | Low | Low | Low | Low | Low |
| Mitchell 201242 | Low | Low | Low | Low | Low | Low | Low |
| Nakamura 200743 | Low | Low | Low | Low | Low | Low | Low |
| Niaura 200844 | Low | Low | Low | Low | Low | Low | Low |
| Nides 200645 | Low | Low | Low | Low | Low | Low | Low |
| Oncken 200646 | Low | Low | Low | Low | Low | Low | Low |
| Plebani 201247 | Unclear | Unclear | Unclear | Unclear | Low | Unclear | Low |
| Plebani 201348 | Low | Low | Low | Unclear | Unclear | Unclear | Low |
| Poling 201049 | Low | Unclear | Low | Unclear | Low | Low | Low |
| Rennard 201250 | Low | Low | Low | Low | Low | Low | Low |
| Rigotti 201051 | Low | Low | Low | Low | Low | Low | Low |
| Shim 201252 | Unclear | Unclear | Low | Unclear | Unclear | Unclear | Unclear |
| Stein 201353 | Low | Low | Low | Low | Low | Low | Low |
| Steinberg 201154 | Low | Low | Low | Low | Low | Low | Low |
| Tashkin 201155 | Low | Low | Low | Low | Low | Low | Low |
| Tonnesen 201356 | Low | Unclear | Low | Low | Low | Low | Low |
| Tonstad 200657 | Low | Low | Low | Low | Low | Low | Low |
| Tsai 200758 | Low | Low | Low | Low | Low | Low | Low |
| Wang 200959 | Low | Low | Low | Low | Low | Low | Unclear |
| Weiner 201160 | Unclear | Unclear | Unclear | Unclear | Low | Unclear | Unclear |
| Williams 200761 | Low | Low | Low | Low | Low | Low | Low |
| Williams 201262 | Low | Low | Low | Low | Low | Low | Low |
| Wong 201263 | Low | Low | Low | Low | Low | Low | Low |
| Zesiewicz 201264 | Low | Low | Low | Low | Low | Low | Low |
| Zhao 201165 | Low | Low | Low | Low | Low | Low | Unclear |