Table 5.
 Comparison of Peto, fixed effects, and random effects odds ratios (OR) for insomnia, sleep disorders, and abnormal dreams in people treated with varenicline
| Neuropsychiatric adverse event | No of events/No treated | Odds ratio (95% CI)* | Test for heterogeneity (%) | |
|---|---|---|---|---|
| Varenicline group | Placebo group | |||
| Insomnia | ||||
| Peto OR | 679/5621 | 379/4762 | 1.56 (1.36 to 1.78), | 0 |
| Fixed effects OR | 679/5621 | 379/4762 | 1.56 (1.35 to 1.79) | 0 |
| Random effects OR | 679/5621 | 379/4762 | 1.56 (1.35 to 1.79) | 0 |
| Sleep disorders | ||||
| Peto OR | 211/5081 | 123/4284 | 1.63 (1.29 to 2.07) | 0 |
| Fixed effects OR | 211/5081 | 123/4284 | 1.57 (1.22 to 2.03) | 0 |
| Random effects OR | 211/5081 | 123/4284 | 1.57 (1.22 to 2.03) | 0 |
| Abnormal dreams | ||||
| Peto OR | 603/5606 | 224/4741 | 2.38 (2.05 to 2.77) | 22.3 |
| Fixed effects OR | 603/5606 | 224/4741 | 2.37 (1.99 to 2.82) | 31.6 |
| Random effects OR | 603/5606 | 224/4741 | 2.36 (1.87 to 2.98) | 31.6 |
*All P<0.001.