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. 2015 Mar 15;26(6):1141–1159. doi: 10.1091/mbc.E14-07-1222

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© 2015 Garcia-Alvarez et al. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

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FIGURE 9: — Model for STIM2-dependent regulation of AMPAR phosphorylation and trafficking at the interface between the ER and the PM. cAMP elevation resulting from synaptic or other signaling inputs triggers translocation of STIM2 to ER-PM contact sites and dynamic assembly of a PKA signaling complex that drives phosphorylation of GluA1 Ser-845 and surface delivery of the AMPAR.