Summarized alterations in PDAC molecular progression genes, for SPC and FPC. a PDAC molecular progression model with reported percent alterations of the four driver genes in PanIN lesions, figure modified from Iacobuzio-Donahue, et al. Clin Cancer Res 2012 [56]. b Percent alterations of molecular progression genes in PDAC cancers from SPC and FPC cohorts. As expected, the mutation prevalence in PDACs in panel b are higher than the early PanIN lesions in panel a. *CDKN2A, p = 0.04