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. Author manuscript; available in PMC: 2016 Apr 1.
Published in final edited form as: Pancreas. 2015 Apr;44(3):441–447. doi: 10.1097/MPA.0000000000000275

Figure 1.

Figure 1

Figure 1

Figure 1A: Histology of L-arginine induced pancreatitis.

Representative photomicrograph of rat pancreatic H&E stained sections. DMF supplementation in rats significantly reduced pancreatic infiltration of inflammatory mediators, destruction of normal acinar architecture, perilobular edema, necrosis of cells and surrounding fat in a rodent model of pancreatitis induced by L-arginine.

Figure 1B: Quantitative pancreatitis score: interstitial edema, leukocyte infiltration, acinar cell destruction

Pancreas histology slides were evaluated by two blinded pathologists and given a score based on severity from 0–3 based on three criteria: edema, infiltration, and acinar cell destruction. Based on quantitative scores for all three criteria there was a significantly higher score for L-arginine compared to L-arginine + DMF (p < 0.001).