Figure 5.
Comparison of [Glu]syn and [Glu]ex under control basal conditions for various glial configurations shown in Figure 4, using the same set of parameters, with configuration G as the baseline model. As expected, porous glia (configuration A) with zero diffusion path length supported no neurotransmitter gradient. The dotted line connects the gradient ([Glu]ex - [Glu]syn) achieved by each of these configurations. The diffusion path length increased from configuration A to G, and this path length was correlated to the neurotransmitter gradient between the ECS and the synaptic cleft.