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. 2015 Mar 5;9:1367–1377. doi: 10.2147/DDDT.S78336

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© 2015 Winnicka et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License

The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

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Representative images of the skin sections.

Notes: (A) Control rats, skin treated with 100 μL of 0.8% formalin (B) and various concentrations of PAMAM-NH₂ generation 2: (C) 3 mg/mL, (D) 6 mg/mL, (E) 30 mg/mL; (F and G) 300 mg/mL. Reported vacuolization of keratinocytes in the basal and spinous layers (arrows) (D), inflammatory infiltrations of leukocytes and connective tissue fibers hyperplasia (dermis) (F and G) and apoptotic keratinocytes (epidermis) and granulocyte infiltration in the upper dermis (F) (arrows). H and E staining, magnification ×200.

Abbreviations: PAMAM, polyamidoamine; SC, stratum corneum; VE, viable epidermis; D, dermis; H and E, hematoxylin-eosin.