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. 2014 Dec 15;43(5):e29. doi: 10.1093/nar/gku1283

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© The Author(s) 2014. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 4. — Examples of new proteoforms. (a) N-terminal extension of DCA13_HUMAN and (b) translated uORF of S35A4_MOUSE that were picked up by the proteogenomics analysis and validated by N-terminal COFRADIC. The UCSC genome browser was used to create a view of the RIBO-seq and COFRADIC data. The different tracks are from top to bottom: CHX-treated RIBO-seq data, LTM/HARR-treated RIBO-seq data, N-terminal COFRADIC data, UCSC genes, RefSeq genes and mRNA. The zoomed-in images show the alternative start site (i, alternative start site; ii, canonical start site), while the MS/MS spectra and sequence fragmentation plots display the confidence and quality of the N-terminal peptide identifications.