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. 2015 Feb 17;43(5):2590–2602. doi: 10.1093/nar/gkv103

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© The Author(s) 2015. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 3. — Association between DNA methylation and gene expression. (A) Local regression showing methylation levels of HD-ALL according to genic locations, stratified by expression quintile. Genes in the highest expression quintile tend to have their promoter unmethylated and gene body mostly methylated. (B) Methylation levels of HD-ALL in CGI and DNase HS, stratified by genic location and expression quintile. Methylation in CGI and DNase HS located around promoter and 5′-body apparently correlated with expression while not in the remaining regions.