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A proposed catalytic cycle of Cid1. The Apo enzyme binds UTP via an induced fit mechanism. The deployment of a structured element, the β trap door, promotes UTP selection. RNA is bound on the surface of the enzyme via basic patches. A single uridylyl ribonucleotide is transferred to the 3′ end of the RNA and pyrophosphate is released. The uridylated RNA product is then ejected from the active site via a structural re-arrangement of the N-terminal domain.
