Fig. 2. Histological features of the excised insulinoma. (A) A grossly resected specimen of the mass at the pancreatic tail shows a multilobulated solid appearance without hemorrhage or necrosis. (B) Low-power view reveals nesting, trabecular, and gyriform arrangement of the tumor with angioinvasion (H&E, ×100). (C) High-power view reveals uniform tumor cells, showing amphiphilic to eosinophilic cytoplasm and a coarsely granular chromatin pattern with mitoses (H&E, ×400). (D) Immunohistochemical staining for insulin reveals diffuse and a strong-positive reaction in the cytoplasm (×200).
