Table 1.
Examples of transcription factors/regulators targeted by some miRNAs examined in this study
| Gene name | Function | miRNA | miRNA expression in HCC |
|---|---|---|---|
| Sox 5 | Transcription factor | has-mir-96 | ↑ |
| E2F1 | Transcription factor | hsa-mir-106b | ↑ |
| E2F5 | Transcription factor | hsa-mir-96 | ↑ |
| hsa-mir-106b | ↑ | ||
| hsa-mir-34a | ↓ | ||
| NFYB | Transcription factor | hsa-mir-222 | ↑ |
| ETS1 | Transcription factor | hsa-mir199a-5p | ↓ |
| Proto-oncogene | hsa-miR-155 | ↑ | |
| MEF2D | Transcription factor | hsa-miR-182 | ↑ |
| BACH2 | Transcription regulator | hsa-miR-182 | ↑ |
| FOXQ1 | Transcription factor | hsa-miR-199a-3p | ↓ |
| CITED2 | Positive regulation of TGFβ receptor signaling Negative regulation of cell migration, motion and apoptosis |
hsa-miR-199a-3p | ↓ |
| PTPRF | Positive regulation of cell development | hsa-miR-199a-3p | ↓ |