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. 2015 Mar 13;5:9092. doi: 10.1038/srep09092

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(A) Specific tubular uptake by organic anion transporters of fluorescent anion 6-CF in serially-reaggregated engineered kidneys cultured for 3, 4 or 6 days after addition of mesenchyme. (B) Specific tubular efflux by the Mrp family of efflux proteins of the fluorescent anion 6-CF in serially-reaggregated engineered kidneys cultured for 3, 4 or 6 days after addition of mesenchyme. (C) Specific tubular uptake by organic cation transporters of fluorescent cation DAPI in serially-reaggregated engineered kidneys cultured for 3, 4 or 6 days after addition of mesenchyme. (D) Tubular uptake of 6-CF by organic anion transporters in the serially-reaggregated engineered kidneys shown in (C), demonstrating presence and functional ability of tubules in these serial reaggregates both with and without the organic cation transporter inhibitors. Scale bars represent 300 μm.