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M3K reaction scheme. (A) The natural substrate of M3K is (R)-mevalonate (MVA), which is converted to (R)-mevalonate-3-phosphate (MVA-3P). (B) PtM3K is also active on 3-hydroxyisovalerate (3-HIV) and 3-hydroxybutyrate (3-HB) to produce 3-phosphoisovalerate (3-PIV) and 3-phosphobutyrate (3-PB), respectively.
