TABLE 1 .
Pathway analysis of essential genes
| KEGG pathway | No. of essential genes | Total no. of genes | Adjusted P value |
|---|---|---|---|
| Ribosomal | 46 | 52 | 9.26 × 10−37 |
| Aminoacyl-tRNA biosynthesis | 23 | 27 | 3.00 × 10−17 |
| Metabolic pathways | 104 | 489 | 2.53 × 10−11 |
| Fatty acid metabolism | 12 | 16 | 6.41 × 10−8 |
| Peptidoglycan biosynthesis | 12 | 19 | 1.08 × 10−6 |
| DNA replication | 9 | 13 | 1.44 × 10−5 |
| Purine metabolism | 18 | 52 | 5.85 × 10−5 |
| Terpenoid backbone biosynthesis | 9 | 14 | 3.20 × 10−4 |
| RNA polymerase | 4 | 4 | 1.26 × 10−3 |
| Protein export | 7 | 13 | 1.8 × 10−3 |
| Lysine biosynthesis | 9 | 21 | 1.41 × 10−3 |
| Pyrimidine metabolism | 14 | 47 | 2.22 × 10−3 |
| Homologous recombination | 8 | 18 | 2.22 × 10−3 |
| Secondary metabolite biosynthesis | 37 | 200 | 5.11 × 10−3 |
| Oxidative phosphorylation | 8 | 21 | 6.33 × 10−3 |
| Mismatch repair | 7 | 18 | 1.07 × 10−2 |
| Folate biosynthesis | 5 | 11 | 2.08 × 10−2 |
| Carbon metabolism | 18 | 86 | 2.25 × 10−2 |
| d-Glutamine and d-glutamate metabolism | 3 | 4 | 2.25 × 10−2 |
| Glycerophospholipid metabolism | 6 | 16 | 2.27 × 10−2 |
| Microbial metabolism in diverse environments | 25 | 137 | 2.80 × 10−2 |
| Biotin metabolism | 4 | 8 | 2.80 × 10−2 |
| Propanoate metabolism | 6 | 17 | 2.81 × 10−2 |
| Pantothenate and coenzyme A biosynthesis | 5 | 13 | 3.51 × 10−2 |
| Nicotinate and nicotinamide metabolism | 4 | 9 | 4.09 × 10−2 |