TABLE 1 .
Group (no. of isolates tested) | MIC in µg/mL |
Bacterial Fitness |
||
---|---|---|---|---|
Vancomycin | Teicoplanin | Daptomycin | Doubling Time (mins) | |
Isolates recovered during 1980s (19) | 1.09 | 0.81 | 0.24 | 39.35 |
Isolates recovered after 1990 (44) | 1.45 | 1.49 | 0.51 | 45.62 |
P = 0.003 | P < 0.001 | P < 0.001 | P < 0.001 | |
Phylogenetic Clade 1 (38) | 1.18 | 0.97 | 0.35 | 43.90 |
Phylogenetic Clade 2 (25) | 1.59 | 1.79 | 0.52 | 43.46 |
P < 0.001 | P < 0.001 | P = 0.021 | P = 0.790 | |
Clade 1 isolates recovered during 1980s (19) | 1.09 | 0.81 | 0.24 | 39.35 |
Clade 1 isolates recovered after 1990 (19) | 1.28 | 1.17 | 0.50 | 48.46 |
P = 0.121 | P = 0.057 | P = 0.013 | P < 0.001 |
Each value is the mean result of the respective group. P values were determined with a Welsh two-sample t test with log transformations applied to MIC data prior to comparison.