Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2015 Mar 13;9:80. doi: 10.3389/fnins.2015.00080

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2015 Palmela, Correia, Silva, Sasaki, Kim, Brites and Brito.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Ursodeoxycholic acid (UDCA) and glycoursodeoxycholic acid (GUDCA) have protective effects on unconjugated bilirubin (UCB)-induced ultrastructural changes in human brain microvascular endothelial cells (HBMEC). A cell line of HBMEC was incubated without (control) or with 100 μM UCB, in the presence of 100 μM human serum albumin, for 48 h. The bile acids (50 μM) were added 1 h prior to the addition of UCB. Representative ultrastructure observations by transmission electron microscopy are shown. In UCB-treated cells note the decrease in mitochondrial cristae (arrows) and ribosomes (arrowhead) and the appearance of detaching cellular fragments (asterisk), which are abrogated by UDCA and GUDCA.