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Proteasome-mediated activator turnover activates transcription. Promoter binding of a transcription activator (TA) results in recruitment of the transcription initiation complex (IC) and RNA Polymerase II (RNAPII). The TA is subsequently phosphorylated (orange star) by a kinase within the IC, marking it for ubiquitination (red diamonds) and degradation by the 26S proteasome. This allows a new TA to bind the promoter and reinitiate a new round of gene transcription.
