Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
High expression of ICN proteins in the cytoplasm and nuclei of NOTCH1-mutated CLL cells, detected by immunofluorescence (x400). The images are representative of three (A) mutated and (B) five unmutated CLL cells. (C) In CLL cells carrying NOTCH1 mutations, the ICN protein was abundantly expressed in the cytoplasm and nuclei, at significantly higher levels than that observed in unmutated and normal CD19+ B cells (*P<0.01).
